CANTERBURY, England  — Britain has been a powerhouse of  discovery since the age of science began. Newton,  Darwin, Crick? They parted the curtain on gravity,  evolution and DNA.
  Now comes Brexit, and to use a non-scientific  term, the scientists in the country are freaking  out.
  Since the vote to leave the European Union last  month, leaders of Britain's scientific academies  are making dire predictions about what could  happen to research and innovation here.
  Damage to British research, the scientists  warn, could be among the cascade of unintended —  and largely unappreciated — consequences of the  vote to exit the bloc.
  The researchers worry that Britain will not  replace funding it loses when it leaves the E.U.,  which has supplied about $    1.2 billion a year  to support British science, approximately 10  percent of the total spent by government-funded  research councils.
  There is a whiff of panic in the labs.
  Worse than a possible dip in funding is the  research community's fear that collaborators  abroad will slink away and the island's  universities will find themselves isolated.
  British research today is networked, expensive,  competitive and global. Being part of a  pan-European consortium has helped put Britain in  the top handful of countries, based on the  frequency of citations of its scientific  papers.
  Last week the heads of British academic  societies posted a public letter reminding  everyone that the country's universities, many  of them among the best in the world, are staffed  by legions of top-flight researchers from  abroad.
  Equally, the student bodies, especially  graduate students in master's and doctoral  programs, are populated by young scholars from the  continent.
  The community is asking: Will the foreigners  continue to be welcome in British laboratories and  will British researchers continue be partners with  collaborators from abroad?
  Dame Jocelyn Bell Burnell, president of the  Royal Society of Edinburgh, said a third of the  research staff at leading universities in Scotland  are E.U. passport holders.
  "They are all very twitchy right now,"  Burnell told a science and technology committee in  Parliament earlier this month. "If good  opportunities show themselves elsewhere in Europe,  they will be off."
  The new prime minister, Theresa May, vowed that  preserving the country's innovation was "a  priority" and that British negotiators would  focus on scientific collaboration in any future  talks in Brussels.
  In a letter to Sir Paul Nurse, director of the  Francis Crick Institute in London and a former  president of the Royal Society, May wrote that  Britain is "enriched by the best minds from  Europe and around the world," according to a  copy of the correspondence obtained by the  BBC.
  Anecdotal evidence suggests head-hunters may  already be circling. Analysts with the Conference  Board of Canada advised that Canadian universities  try to lure talent across the ocean: "With  Britain's wealth of talent facing an uncertain  future after Brexit, we can reasonably expect them  to consider their international options."
  Spain's deputy prime minister, Soraya Sáenz  de SantamarÃa, told the Financial Times her  country would like to see the European Medicines  Agency move from London to Madrid.
  Some 15 percent of lecturers at British  universities hold E.U. passports (and are not  British). At the highest-ranked British  universities, the number rises to 20 percent. In  some academic departments at the London School of  Economics, half of the teaching staff are from  abroad.
   Alexander Halliday, a professor of  geochemistry at the University of Oxford,  testified at the House of Lords. Britain, he said,  is considered one of the most entrepreneurial  places in the world. "It wasn't that way 10  years ago," he said, and pointed to a surge in  E.U. science spending compared with flatline  funding by Britain.
  As one example of Britain's ability to draw  talent, Halliday said a "staggering"  one-fourth of the winners of the coveted Marie  Curie Fellowship, awarded by the E.U. to  scientists to study abroad, come to Britain.
  Here in Canterbury, the University of Kent  bills itself as "the U.K.'s European  university," with outposts in Athens, Brussels,  Paris and Rome. The vice chancellor, Dame Julia  Goodfellow, said of her location in Kent,  "We're surrounded by sea on three sides.  It's an hour to London but almost as quick to  Paris or Brussels. It just makes sense to look  outside Britain."
  Europeans make up 18 percent of Kent's  graduate students and 22 percent of the faculty.  The university pumps almost $    1 billion a year  into the local economy.
  "One of our biggest issues right now is the  uncertainty," Goodfellow said. Researchers and  students want to know they'll get visas and  funding. "Kent will push for an open-door  policy," she said.
   Harmonie Toros, 42, is a senior lecturer at  the University of Kent, where her speciality is  international conflict resolution. She is  French-Turkish, and her husband is an Italian  academic also at the university. They have two  young children.
  She said Brexit has hit her professionally and  personally.
  "Professionally, I would be planning to apply  for a European Research Council grant now. It  would be the right thing to do in my career. But  it is a huge undertaking, 90 pages, will take a  month and a half to do. And my chances of getting  it are between 5 and 10 percent."
  She's worried those odds may have fallen in  the wake of Britain's decision to leave the  European Union.
  "I would understand if the European Research  Council weren't particularly inclined to give us  as much money as they used to," Toros said.  "Do I put a month of my time or more into an  application I will have even lesser chance of  getting? There are quite a few of us in this kind  of position asking, 'Is it really worth  it?' "
  On the personal side, Toros said that for the  first few weeks after Brexit, she would eye people  on the streets and wonder how they voted. The  county of Kent came out strongly in favor of  leaving the union.
  "You look at neighbors, and you know some of  your neighbors voted 'leave,' " she said.  "My entire work is on dialogue. I'm not going  to stop talking to people because they voted  'leave.' That would be crazy."
  Vid Calovski is president of the Kent Graduate  Student Association. He said, "We're scared  the vote will change what makes the university  such an eclectic community."
  A friend, Paul Wong, 23, who is from Malaysia  and is studying for a master's in actuarial  science, said that in his class of 30 students,  none are from Britain. Another graduate student,  Ben Brown, 22, who is getting a master's in  comparative politics, ticked off his roommates in  a student apartment: "Four French, an American,  one German, a Dutch — and me." He's the lone  Brit.
  Research in the 21st century is more  collaborative than ever, the scientists say.
  Anne Rosser is a professor at Cardiff  University in Wales and a joint director of the  Brain Repair Group there. Her focus is  Huntington's disease, a rare neural disorder.  With partners at eight other labs, the consortium  is searching for ways to transplant stem cells  into damaged brains.
  "You can't do this kind of research in one  country," Rosser said. She is especially worried  about what will happen to funding and  collaboration for investigating rare diseases.
  Asked if Brexit could hurt her research, she  said, "It could certainly slow down what we are  doing."
  Rosser said she will apply for European funding  this year, but she added that scientists are  growing anxious about eligibility.
  "In science, the last thing you want is  isolation," she said.
  Chris Husbands, vice chancellor of Sheffield  Hallam University, said 12 research groups at his  institution were preparing to participate in grant  applications for the E.U.'s Horizon 2020 money,  due in August. He said that four of the teams on  his campus were told by their E.U. partners that  it was unhelpful now to have British  collaborators.
  The scientific journal Nature rightly pointed  out that much of the anxiety in British science is  so far based on anecdotal evidence — as well as  mere emotions — which are unreliable for proving  that British innovation is going to take a  whack.
  Regardless, Nature reported that Britain's  science minister, Jo Johnson, has set up a  specific email address (research@bis.gsi.gov.uk)  for researchers to send him stories of lost  opportunities.
     william.booth@washpost.com  
     karla.adam@washpost.com  
  Adam reported from  London.
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